The American Civil Liberties Union, the ACLU of New Hampshire and the Americans United for Separation of Church and State are challenging a statewide tuition tax-credit program in New Hampshire that would divert taxpayer funds to private religious schools in violation of the state constitution. The lawsuit was filed on behalf of eight plaintiffs, including clergy, public education advocates and parents of public school children.

The American Civil Liberties Union and the ACLU of South Carolina have filed a lawsuit challenging a pervasive practice of school-sponsored prayer, preaching and religious activities in the Chesterfield County School District. The lawsuit was filed on behalf of a student and his father (both non-believers) who have been ostracized for their objection to repeated official religious events and activities at New Heights Middle School.

In the spring of 2010, officials at the Connecticut-based Enfield Public Schools decided to hold their graduation ceremonies at First Cathedral, a Christian church. The American Civil Liberties Union, the ACLU of Connecticut and Americans United for Separation of Church and State brought a lawsuit in federal court charging that the Enfield Public Schools' decision is an unconstitutional government endorsement of religion.

The American Civil Liberties Union and the ACLU of Eastern Missouri have filed a lawsuit charging the Salem Public Library and its board of trustees with unconstitutionally blocking access to websites discussing minority religions by improperly classifying them as “occult” or “criminal.”

Whether the Americans with Disabilities Act may be constitutionally applied to a religious school's retaliatory firing of a teacher terminated for reasons unrelated to religion.